Can anyone tell me if a tuned ECM from another truck will go into my truck with no issues? Both are OBD2, only difference is his is 4.10 drive ratio, I have 3.73's.
Final ratio is irrelevant. The 6.5 trucks use a VSSB to condition the VSS signal and send it out to the various components. The PCM isn't involved other than getting the conditioned signal from the VSSB for the calibration tables. The VSSB is where the ratio correction is stored and calculated. You can change that (IE: speedo correction, ODO, etc) by moving the soldered jumpers inside the VSSB or installing a set of DIP switches in place of the jumpers.
With OBDII, swapping a different PCM might work, or it might not.
Although all the OBDII trucks use the 16216588 PCM, they use different calibration by year. In some cases, more than one calibration in a single year.
For example: I've flashed a 98 calibration in a 16216588 and it ran my 98 just fine (as it should). We took that same PCM/Calibration and dropped it into a 97 K2500 (L65 like mine) and no go. Wouldn't run. No matter what we tried (I never looked into the PCM pinouts for it, so can't say if that was it). Had to buy a 1997 VDF and Cal file in order to properly alter, upload and run the 97.
Don't ask me why, I've never bothered to go that deep into it. Different pin assignments is the likely cause. Dunno for sure, never bothered to trace it out.
If you go to Wester's website and scroll through his stuff, you can see a separate calibration for each year and some have more than that per year.
At the end of the day, the answer is still maybe. More likely to work if it's the same year, but even then its still just a maybe. The more than one cal in a year deal is in later years. Around 98+.
Only way to know for sure is to plug it in and give it a try.