The finer a filter is, the more it restricts. Many filters are rated at a low micron level, but don't actually achieve that level 100% of the time. At that level 50% of the time they can be rated it. I mention this because many companies abuse the numbers for advertising- posting infomon the filter you find is well worth it before buying. Fuel filters are just like oil filters- many that are touted as the superior turn out to be horrible.
So finer flow filters being more restrictive -slowing the volume of fuel, they make the filter larger to compensate, or much more frequent changes. The added restriction generally requires an improved pump, so people upgrade the system, not just one component.
Going in the commercial marine world really sheds light on to best fuel systems are done (centrifuge). But $7,000 -$10,000 for a system doesn't make sense in a little pick up.
Anyone that has a large enough fleet of vehicles to buy fuel and store it in their own tanks could install a driven centrifuge eliminating any contaminants.
If you had the powered bypass centrifuge and used it to batch your fuel at home through a couple barrels you could achieve the same thing, but back to the real world...
So having a fuel pressure gauge before your injection pump is the only way to tell you're not restricting the fuel too much, and of course running the filters with your fuel line disconnected prior to IP and feeding into a container to measure your volume of flow to verify you are not damaging IP through starvation.
Remember that all pumps "pump". Pumps do not "suck" by design, so a filter to save the pump also adds wear to the pump sucking fuel through any filter, but a $250-$400 pump is worth saving from a pebble which opens the question of pre pump filters, another can of worms.
You mention Mr. gasket pump, but the few Mr. gasket ones I have seen are very low-quality. What is the volume and pressure of the Mr. gasket pump you are using? If unkown, what model number or any pics?
The OEM canister style pumps, AC Delco EP158 being the best of those versions, barely gets the job done for a DS4 IP. Does ok for a stock db2. Having a finer filter after it would really make me question its use. Upgrading a fuel pump and filtering system is normally done at the same time. To try using the factory pump and that fine of a filter- you would have to expirement.
It would help to fill out your signature so we can see what exactly you are running currently.