Hi war,
My 'thing' here is simple, making it as reliable as is possible with what's in it. My truck is rated for 9,000 GVW and 10k towing, that's about as heavy duty as a 2500 gets. I wouldn't even think to load heavier than that, especially with the 6.5. The 6.5 is simply not built for heavy use in the first place. Even stock many of this engine series don't make it very long. Fortunately, I have one of the better ones with no issues. I think the only reason it has survived to 245k is specifically due to the fact that it was NOT modified or abused. Why anyone would push it to 14psi or higher is beyond me. Am surprised that they don't come apart the first time, let alone live very long at that kind of pressure. It's no wonder you have gone thru lots of engines.
You can change turbo's, exhaust, prom's, and do all the "tweaks" you want but it is still a 6.5 engine that was designed over 20 years ago for economy and EPA, NOT long distance towing. They have some basic faults that can be dealt with for good economy and long term reliability and that's where my head is at with this truck. Once I have figured them all out I will drop in the crated AMG 6.5 and 4L80E that came with it.
Here are a few things I have learned about the 6.5 so far, only certain casting numbers will run very long, coolant temps above 210--bad news, #8 cylinder cracks, #2 blows head gasket, main bearing web cracks, harmonic balancer dies--destroys crank, stock fan and clutch hub inadequate, standard radiator marginal even without a load, standard glow plugs quit and swell up-can break off or jam in head, glow plug controller timing problems and flakey, injectors leak and have lousy pattern, several issues with IP, fuel filter canister has too small an outlet, lift pump control issues, engine oil cooler line problems, electrical grounding problems, exhaust manifolds flow poorly, exhaust crossover does not blend properly, exhaust from turbo back restrictive, waste gate design crappy, waste gate control flakey.
Did I miss anything??? And yet they were made for 15 years, maybe more. Last point, GM had to put the soot trap on the 8600 GVW and up so, to not have it plug up right away, they needed to get high EGT's to clean it out, only it didn't work very well for that or the rest of the system.