I pour in some gear oil and pack as much grease in the back side as I can when I have the C/V shafts out of the hub.
I think the 2500HD/3500 hubs are alot more robust than the 1500/2500LD, I've replaced around ten half ton hubs and only one 1ton hub. Slap a heavier diesel in a half ton and I can see where failure rates would go up exponentially, all the half ton ones I replaced were on lighter gassers.
I had a 89 2500LD 350 gasser and it would go through hubs about every 100k.
My 92 2500HD has 350k on the original hubs and they still feel tight/smooth, but it saw very little mud/deep water the first 200k, mainly highway towing, I replaced ball joints/C/V boots @200k and ball joints again around 300k lubing the hubs each time it was apart.
But its good piece of mind having new parts.
Its hard to say when these will fail, like my feed truck I wouldn't be surprised if they only last 50k caring all that weight running eight inches sloppy watery mud/manure in lots and pastures, where as a strictly highway truck prolly would go 500k with a little maintenance. Best to check periodically with a dial indicator for slack, see how they feel and replace if in doubt.
Be careful of aftermarket parts, most are not near the quality of factory GM, compare prices, shop around, then make a decision. Moog aint the quality of GM, but there prolly the best aftermarket you can get. I'd think you cant go wrong with Timken hubs. If you use Moog, get your part numbers and order them from summit and save about 30%, that's what I do.