What I have noticed, over many, many tests, with many different mods is that I actually get my best mileage with my programming set on the higher settings.
Let the torque do the work and not the HP and your mileage goes up nicely.
I get much better mileage imporvements with the Smarty (with the Revo tuning) than I do with my Edge. I noticed no gains at all with the Edge.
What you need to do is turn off the torque management, increase the rail pressure (VERY slightly) and bump up the timing to get rid of the EPA timing. The timing is big one.
Adjust the Tq Mgmt until you see smoke under normal acceleration and then back off one setting.
Turn the rail pressure up to mild.
Bump the timing up until you begin to hear timing rattle. It sounds like marbles in the engine under acceleration. Then back it off to where you don't hear it.
On my truck, running with the mods I have, I net 17 - 19 MPG in day to day driving and 20 - 21.5 on the highway at 72 MPH.
Now, here is what you want to look for when driving..........YOU NEED GOOD GAUGES TO DO THIS.
1 - Boost. Keep boost number in the single digits
2 - EGT's. EGT's at cruise, on flat and level ground, should be in the 550 - 700 range
3 - RPM's. Keep them below 2000. That's where you are getting into the high point of the CTD fuel consumption
If your Boost is high and the EGT's are low, you're probably running too high on the RPM's vs engine load and you're wasting fuel.
If your EGT's are high and boost is low, you are lugging the engine and using more fuel than can be burned. Drop a gear or speed UP to get the numbers in check.
Balancing the boost, EGT's, RPM and engine load is where you'll see good mileage gains.
My best mileage, on three 600 mile legs from Columbus, Georgia to St Louis, MO to Columbus, OH and back to Columbus, GA was 23.7 MPG (hand calculated).