It's easy to do...you only need a couple...CCleaner is good to clean up loose ends that the scanner programs (antispyware, etc.) take out. They leave little fingers all over and it cleans those out.
As per the thread I started about your puter wearing protection, I now use mostly three for scanning...Spybot, Adaware, and SuperAntiSpyware.
These are scanning programs.
Those are seperate from other programs like McAfee, BitDefender, and the like.