Here are mpg enhancing ideas gleaned from my experience and theories (the ones that most of you wont like, as most of you want big rubber and no rake!

) and the rest are what I have learned over the years from the fine members of this forum.
1) support our own resident oil geek, Wrecker, and he will hook you up with amsoil for a good price. synthetic oil will help on mpg, longevity, and durability, so the only downside is cost, and he makes synthetics affordable.
2) find an airdam, junkyard, LMC truck, etc. I believe GM sells them for (last check 2 years ago) 55, 57 bucks. this will divert the air around the truck, rather than under it. plus, there is some debate whether or not this will help your cooling system out, as it supposedly lowers the under vehicle air pressure, encouraging more airflow through the engine bay.
3) lowest rolling resistance rubber possible, and light rims. this is where you find a local wheel retailer that buys the new takeoff stuff from conversion companies and dealers that put big rubber on. you then buy the OEM alloys found on 2500HD GM trucks with the wimpy highway tread bridgestone 245/75R16s.
4) keep, or return to stock suspension height. this is the most aerodynamic, but in somes opinion, the worst looking.
5) hot factory t-stats: 195 degrees!
6) mandrel bent 4 inch exhaust (with the high velocity 3 inch DP) and mandrel bent crossover. mandrel bends are smooth, so this will allow better flow than a straight piped factory system
7) Fresh rebuilt injectors, I dont know what kind of workload he can handle, but bk95td is geared up for rebuilding these.
8) 3.42s (if funds allow, and it is alot of highway travel) this will lower your engine RPMs closer to the desired 1800-1900 RPM, supposedly the best RPM range for MPG
9) ATT better mpg, lower temps (IAT and EGT) everyone on this forum who has one seems to love it. it is also known the GM series of turbos are quite restrictive, GM8 being the least, so if your funds only allow used, go with a GM8, but the ATT will get you the biggest jump.
10) personal driving and operating characteristics: keep a light foot, a/c off as much as possible, windows up, rolling stops (if you can get away with it with the local P/D) slower speeds, etc.
11) engine timing, programming. I will stop here and let someone else explain it right, but fine tuning the powertrain via electronics will help you with mpg and power.